Conference Title
Location
Day Month Year
Previous Conference Programme, 2009
Click here to download Immune Tolerance 2009 Programme 
| Sunday October 25 | ||
| 2.00 | Welcome and Introduction | |
| Session 1 - Setting the scene: Chair – Diane Mathis | ||
| 2.10 | Diane Mathis Harvard Medical School, USA |
Initiation of arthritis by commensal microbes |
| 2.35 | Shimon Sakaguchi University of Kyoto, Japan |
T cell signaling, regulatory T cells, and self-tolerance |
| 3.00 | Maria-Grazia Roncarolo San Raffaele Telethon Institute for Gene Therapy, Italy |
The Interplay Between Natural Treg and Tr1 Cells |
| 3.25 | Edward Wakeland University of Texas, USA |
Common Features of Systemic Autoimmunity in Man and Mouse |
| 3.50 – 4.15 | Coffee Break | |
| Session 2 - Basic T and B cell tolerance: Chair – Betty Diamond | ||
| 4.15 | Betty Diamond North Shore LIJ Health System, USA |
Establishing the B cell repertoire |
| 4.40 | Leo Lefrancois University of Connecticut, USA |
Dynamics of peripheral CD8 T cell tolerance induction |
| 5.05 | Oral 1: Yan Su University of Maryland, USA |
B Cells Activated Via TLR4 and TLR9 Have Opposite Effects on Tolerance Induction |
| 5.20 | Oral 2: Philippe Bouillet Walter and Eliza Hall Institute, Australia |
FAS, BIM and T cell homeostasis |
| 5.35 | Oral 3: Pamela Fink University of Washington, USA |
T Cell Receptor Revision as a Tolerance Mechanism |
| 5.50 | Oral 4: Nahzli Dilek UMR 643 INSERM, France |
Difference Between CD28 Blockade and B7 Blockade On T Cell Activity Controlled by CTLA-4 Dependent Mechanisms |
| 6.05 | Oral 5: Woelsung Yi Sloan Kettering NY, USA |
Targeted Regulation of Self-peptide Presentation by HLA-DO Prevents Type I Diabetes without Disrupting General Immunocompetence |
| 6.20 | Oral 6: Martin Kriegel Harvard Medical School, USA |
E3 Ubiquitin Ligase GRAIL Controls Primary T Cell Activation and oral Tolerance |
| 6.35 - 8.30 | Welcome reception and poster session 1 | |
| Monday October 26 | ||
| Session 3 - Innate role of immune tolerance: Chair - Dennis Kasper | ||
| 8.00 | Cees van Kooten Leiden University Medical Center, The Netherlands |
A radical way to induce immune regulation |
| 8.25 | Dennis Kasper Harvard Medical School, USA |
Bacterial carbohydrates of the intestinal microbiota in health and disease |
| 8.50 | Oral 7: Raymond Steptoe University of Queensland, Australia |
Targeting Antigen to Diverse Antigen-Presenting Cell Types Terminates Memory CD8+ T-Cell Responses Without Eliciting Tissue-Destructive Effector Function. |
| 9.05 | Oral 8: Megan McCloskey New York University School of Medicine, USA |
Follicular Dendritic Cells Act as Antigen Capacitors to Prolong the CD8 T Cell Response |
| 9.20 | Oral 9: Simon Gaudreau University of Sherbrooke, Canada |
GM-CSF Induces the Precursors of Bone Marrow Dendritic Cells of NOD Mice to Skew to Tolerogenic Dendritic Cells. |
| 9.35 | Oral 10: Adam Lacy-Hulbert MGH/ Harvard Medical School, USA |
Alpha (v) integrins expressed by innate immune cells regulate local immune tolerance |
| 9.50 | Oral 11: Petter Brodin MTC, Karolinska Institute, Sweden |
NK cell self tolerance is secured by an education process resembling a rheostat rather than an onoff switch |
| 10.05 | Oral 12: Francesca D'Addio Brigham & Women's Hospital and Children's Hospital, USA |
Regulatory T cell epitope IgG Fc derived peptide (Tregitope) modulates tolerance/immunogenicity balance in murine and human allo-antigen stimulation models |
| 10.20 - 10.40 | Coffee Break | |
| Session 4 - Role of viruses and bacteria: Chair - Nora Sarvetnick | ||
| 10.40 | Yasmine Belkaid NIH/NIAID, USA |
Role of commensals in the control of peripheral tolerance |
| 11.05 | Nora Sarvetnick University of Nebraska Medical Center, USA |
Mechanism of virus induced autoimmunity |
| 11.30 | Oral 13: Dorothy Sojka University of Rochester, USA |
Bridging the In Vitro - In Vivo Divide: IL-10- Dependent Treg Suppression of IFNg, but not IL- 2, Production in CD4 T Cells During Th1 Priming |
| 11.45 | Oral 14: Steve Levin ZymoGenetics, Inc., USA |
Soluble Vstm3 attenuates disease development in mouse models of human autoimmune diseases |
| 12.00 | Oral 15: Hongbo Chi St. Jude Children's Research Hospital, USA |
Negative control of regulatory T-cell mediated immune tolerance by SIPI and AKT-m TOR signalling |
| 12.15 | Oral 16: Loise Francisco Harvard Medical School; Brigham& Women's Hospital, USA |
PD-L1 regulates the development, maintenance and function of induced regulatory T cells in vitro and in vivo |
| 12.30 | Oral 17: Linde Meyaard UMC Utrecht, The Netherlands |
CD200 controls pathological T cell responses during influenza infection |
| 12.45 - 1.45 | Lunch and 'SciVal Funding workshop' | |
| Session 5 - Regulatory T cells: Chair - Mohamed Sayegh | ||
| 1.45 | Mohamed Sayegh Harvard Medical School, USA |
Interactions between Tregs and immunosuppression in transplantation |
| 2.10 | Herman Waldmann University of Oxford, UK |
Explaining infectious tolerance? |
| 2.35 | Oral 18: Per thor Straten Center for Cancer Immune Therapy, Denmark |
Identification of highly potent regulatory CD8+ Tcells specific for Heme Oxygenase-1 |
| 2.50 | Oral 19: Terrence Geiger St. Jude Children's Research Hospital, USA |
CDR3 structural features but not recognition characteristics distinguish autoreactive Foxp3+ regulatory and effector T cells |
| 3.05 | Oral 20: Anne De Groot EpiVax Inc, USA |
Effect of "Tregitopes" on T1D immune response in vitro and diabetes in NOD mice |
| 3.20 | Oral 21: Michael Mingueneau Harvard Medical School, USA |
LAT signaling pathologies (LSP): an Auto-immune condition without Self-reactivity |
| 3.35 | Oral 22: Rosa Bacchetta HSR TIGET, Italy |
Analysis of the Demethylation Status of FOXP3 allows reliable identification of Quantitative Treg Cells Defects in Children with Multiple Autoimmunity of Genetic or Unknown origin |
| 3.50 - 4.15 | Coffee Break | |
| Session 6 - Role of target tissue and its antigens: Chair – Joan Goverman | ||
| 4.15 | Joan Goverman University of Washington, USA |
Novel mechanisms of tolerance induction in CD8+ MBP-specific T cells |
| 4.40 | Stephen Miller Northwestern University, USA |
An Antigen-Specific Tolerance Approach to Therapy of Autoimmune Disease and Tissue Transplantation |
| 5.05 | Oral 23: MS Arredouani Beth Israel Deaconess Medical Center/Harvard Medical School, USA |
Targeting Tim-1 to circumvent immune tolerance to prostate tumor-associated antigens |
| 5.20 | Oral 24: Kimberly Schluns UT MD Anderson Cancer Center, USA |
Defining the in vivo role of IL-15 in CD8αα IEL development using a intestinal specific IL-15Rα transgenic model |
| 5.35 | Oral 25: Jacqueline Shields Ecole Polytechnique Federale de Lausanne, Switzerland |
Lymph node mimicry by tumors induces immunological tolerance |
| 5.50 | Oral 26: Phil Askenase Yale Medical School, USA |
Regulation of skin immunity by suppressive intercellular RNA via exosomes |
| 6.05 | Oral 27: Linda Yip Stanford University, USA |
Differential regulation of peripheral tissue antigen expression by Deaf1 isoforms in the pancreatic lymph node during Type 1 diabetes |
| 6.20 | Oral 28: Bruce Hall University of New South Wales, Australia |
IL-5 promotes induction of antigen specific CD4+ CD5 Tregs that suppress autoimmune mediated demyelination |
| 7.30 | Coaches depart for Conference dinner at the Museum of Science from the front of the Seaport Hotel | |
| Tuesday October 27 | ||
| Session 7 – Cytokines: Chair - Chen Dong | ||
| 8.30 | Chen Dong University of Texas, USA |
Molecular control of T cell tolerance and function |
| 8.55 | Burkhard Becher University Hospital of Zurich, Switzerland |
Th17 derived factors: the target organ matters |
| 9.20 | Oral 29: Rikke Bæk Sørensen University Hospital Herlev, Denmark |
Immunogenicity of IDO |
| 9.50 | Oral 30: V.A. Boussiotis Beth Israel Deaconess Medical Center, USA |
Rap1 reduces the threshold of TGF-beta mediated signalling in T cells |
| 10.05 | Oral 31: Su M. Metcalfe University of Cambridge, UK |
Treg and "Stemness": Leukaemia Inhibitory Factor (LIF) is a Treg Cytokine |
| 10.20 | Oral 32: RA Maldonado Harvard Medical School, USA |
Rapamcycin and TGFb treated Dendritic Cells induce tolerance and denovo differentiation of regulatory T cells in vitro and in vivo |
| 10.35 - 12.00 | Coffee Break and poster session 2 | |
| Session 8 - Genetic studies pertaining to tolerance: Chair - David Hafler | ||
| 12.00 | David Hafler Yale School of Medicine, USA |
The Genetic Basis of Human Autoimmune Disease |
| 12.25 | George Eisenbarth University of Colorado, USA |
Trimolecular Complex and Endocrine Autoimmunity |
| 12.50 | Oral 33: Jerry Nepom Benaroya Research Institute, USA |
Genetic determinants of avidity-dependent autoreactivity |
| 1.15 | Oral 34: Laura Esposito Cambridge Institute for Medical Research, UK |
Expression of CTLA-4 protein in human Tregs is dependent on CTLA4 genotype |
| 1.30 - 2.30 | Lunch and Workshop: 'Immunology & Publishing - Insights into what authors, editors and journals want' |
|
| Session 9 – Migration: Chair - Marc Jenkins | ||
| 2.30 | Ulrich von Andrian Harvard Medical School, USA |
Short- and long-term consequences of dynamic T cell interactions with dendritic cell |
| 2.55 | Marc Jenkins University of Minnesota Medical School, USA |
Assessing clonal deletion of polyclonal self-reactive CD4+ T cells |
| 3.20 | Oral 35: Tom Li Stephen University of Pennsylvania, USA |
T cell receptor/MHC class II interactions in the thymic medulla set the activation threshold of CD4 T cells |
| 3.35 | Oral 36: Cynthia Guidi University of Virginia, USA |
Lymph Node-Resident Lymphatic Endothelial Cells Mediate Tolerance to Tyrosinase via Direct Presentation and in an Aire-independent Manner |
| 3.50 | Kevan Herold Yale University School of Medicine, USA |
Immune therapies for autoimmune diseases: Thinking out of the box |
| 4.20 | Panel Discussion led by Kevan Herold | |
| 4.50 | Closing remarks and end of conference | |
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