Click here for the Poster Program
Sunday October 25, 2009
14.00
Welcome and Introduction
Session 1 - Setting the scene
Chair – Diane Mathis
14.10
Initiation of arthritis by commensal microbes
Diane Mathis, Harvard Medical School, USA
14.35
T cell signaling, regulatory T cells, and self-tolerance
Shimon Sakaguchi, University of Kyoto, Japan
15.00
The interplay between natural Treg and Tr1 cells
Maria-Grazia Roncarolo, San Raffaele Telethon Institute for Gene Therapy, Italy
15.25
Common features of systemic autoimmunity in man and mouse
Edward Wakeland, University of Texas, USA
15.50
Coffee Break
Session 2 - Basic T and B cell tolerance
Chair – Betty Diamond
16.15
Establishing the B cell repertoire
Betty Diamond, North Shore LIJ Health System, USA
16.40
Dynamics of peripheral CD8 T cell tolerance induction
Leo Lefrancois, University of Connecticut, USA
17.05
B Cells activated via TLR4 and TLR9 have opposite effects on tolerance induction
Oral 1: Yan Su, University of Maryland, USA
17.20
FAS, BIM and T cell homeostasis
Philippe Bouillet, Walter and Eliza Hall Institute, Australia
17.35
T Cell receptor revision as a tolerance mechanism
Pamela Fink, University of Washington, USA
17.50
Difference between CD28 Blockade and B7 blockade on T cell activity controlled by CTLA-4 dependent mechanisms
Nahzli Dilek, UMR 643 INSERM, France
18.05
Targeted regulation of self-peptide presentation by HLA-DO prevents type I diabetes without disrupting general immunocompetence
Woelsung Yi, Sloan Kettering NY, USA
18.20
E3 Ubiquitin Ligase GRAIL controls primary T cell activation and oral tolerance
Martin Kriegel, Harvard Medical School, USA
18.35 - 20.30
Welcome reception and poster session 1
Monday October 26, 2009
Session 3 - Innate role of immune tolerance
Chair - Dennis Kasper
08.00
A radical way to induce immune regulation
Cees van Kooten, Leiden University Medical Center, The Netherlands
08.25
Bacterial carbohydrates of the intestinal microbiota in health and disease
Dennis Kasper, Harvard Medical School, USA
08.50
Targeting antigen to diverse antigen-presenting cell types terminates memory CD8+ T-Cell responses without eliciting tissue-destructive effector function
Raymond Steptoe, University of Queensland, Australia
09.05
Follicular dendritic cells act as antigen capacitors to prolong the CD8 T cell response
Megan McCloskey, New York University School of Medicine, USA
09.20
GM-CSF induces the precursors of bone marrow dendritic cells of NOD mice to skew to tolerogenic dendritic cells
Simon Gaudreau, University of Sherbrooke, Canada
09.35
Alpha (v) integrins expressed by innate immune cells regulate local immune tolerance
Adam Lacy-Hulbert, MGH/ Harvard Medical School, USA
09.50
NK cell self tolerance is secured by an education process resembling a rheostat rather than an on-off switch
Petter Brodin, MTC, Karolinska Institute, Sweden
10.05
Regulatory T cell epitope IgG Fc derived peptide (Tregitope) modulates tolerance/immunogenicity balance in murine and human allo-antigen stimulation models
Francesca D'Addio, Brigham & Women's Hospital and Children's Hospital, USA
10.20
Coffee Break
Session 4 - Role of viruses and bacteria
Chair - Nora Sarvetnick
10.40
Role of commensals in the control of peripheral tolerance
Yasmine Belkaid, NIH/NIAID, USA
11.05
Mechanism of virus induced autoimmunity
Nora Sarvetnick, University of Nebraska Medical Center, USA
11.30
Bridging the in vitro - in vivo divide: IL-10-dependent treg suppression of IFNg, but not IL-2, production in CD4 T cells during Th1 priming
Dorothy Sojka, University of Rochester, USA
11.45
Soluble Vstm3 attenuates disease development in mouse models of human autoimmune diseases
Steve Levin, ZymoGenetics, Inc., USA
12.00
Negative control of regulatory T-cell mediated immune tolerance by SIPI and AKT-m TOR signalling
Hongbo Chi, St. Jude Children's Research Hospital, USA
12.15
PD-L1 regulates the development, maintenance and function of induced regulatory T cells in vitro and in vivo
Loise Francisco, Harvard Medical School; Brigham & Women's Hospital, USA
12.30
CD200 controls pathological T cell responses during influenza infection
Linde Meyaard, UMC Utrecht, The Netherlands
12.45
Lunch and 'SciVal Funding workshop'
Session 5 - Regulatory T cells
Chair - Mohamed Sayegh
13.45
Interactions between Tregs and immunosuppression in transplantation
Mohamed Sayegh, Harvard Medical School, USA
14.10
Explaining infectious tolerance?
Herman Waldmann, University of Oxford, UK
14.35
Identification of highly potent regulatory CD8+ T-cells specific for Heme Oxygenase-1
Per thor Straten, Center for Cancer Immune Therapy, Denmark
14.50
CDR3 structural features but not recognition characteristics distinguish autoreactive Foxp3+ regulatory and effector T cells
Terrence Geiger, St. Jude Children's Research Hospital, USA
15.05
Effect of "Tregitopes" on T1D immune response in vitro and diabetes in NOD mice
Anne De Groot, EpiVax Inc, USA
15.20
LAT signaling pathologies (LSP): an Auto-immune condition without Self-reactivity
Michael Mingueneau, Harvard Medical School, USA
15.35
Analysis of the demethylation status of FOXP3 allows reliable identification of quantitative treg cells defects in children with multiple autoimmunity of genetic or unknown origin
Rosa Bacchetta, HSR TIGET, Italy
15.50
Coffee Break
Session 6 - Role of target tissue and its antigens
Chair – Joan Goverman
16.15
Novel mechanisms of tolerance induction in CD8+ MBP-specific T cells
Joan Goverman, University of Washington, USA
16.40
An antigen-specific tolerance approach to therapy of autoimmune disease and tissue transplantation
Stephen Miller, Northwestern University, USA
17.05
Targeting Tim-1 to circumvent immune tolerance to prostate tumor-associated antigens
MS Arredouani, Beth Israel Deaconess Medical Center/Harvard Medical School, USA
17.20
Defining the in vivo role of IL-15 in CD8αα IEL development using a intestinal specific IL-15Rα transgenic model
Kimberly Schluns, UT MD Anderson Cancer Center, USA
17.35
Lymph node mimicry by tumors induces immunological tolerance
Jacqueline Shields, Ecole Polytechnique Federale de Lausanne, Switzerland
17.50
Regulation of skin immunity by suppressive intercellular RNA via exosomes
Phil Askenase, Yale Medical School, USA
18.05
Differential regulation of peripheral tissue antigen expression by Deafl isoforms in the pancreativ lymph node during Type 1 diabetes
Linda Yip, Stanford University, USA
18.20
IL-5 promotes induction of antigen specific CD4+ CD5 Tregs that suppress autoimmune mediated demyelination
Bruce Hall, University of New South Wales, Australia
19.30
Coaches depart for Conference dinner at the Museum of Science from the front of the Seaport Hotel
Tuesday October 27, 2009
Session 7 – Cytokines
Chair - Chen Dong
08.30
Molecular control of T cell tolerance and function
Chen Dong, University of Texas, USA
08.55
Th17 derived factors: the target organ matters
Burkhard Becher, University Hospital of Zurich, Switzerland
09.20
Immunogenicity of IDO
Rikke Bæk Sørensen, University Hospital Herlev, Denmark
09.50
Rap1 reduces the threshold of TGF-beta mediated signalling in T cells
V.A. Boussiotis, Beth Israel Deaconess Medical Center, USA
10.05
Treg and "Stemness": Leukaemia Inhibitory Factor (LIF) is a Treg Cytokine
Su M. Metcalfe, University of Cambridge, UK
10.20
Rapamcycin and TGFb treated Dendritic Cells induce tolerance and denovo differentiation of regulatory T cells in vitro and in vivo
RA Maldonado, Harvard Medical School, USA
10.35
Coffee Break and poster session 2
Session 8 - Genetic studies pertaining to tolerance
Chair - David Hafler
12.00
The genetic basis of human autoimmune disease
David Hafler, Yale School of Medicine, USA
12.25
Trimolecular complex and endocrine autoimmunity
George Eisenbarth, University of Colorado, USA
12.50
Genetic determinants of avidity-dependent autoreactivity
Jerry Nepom, Benaroya Research Institute, USA
13.15
Expression of CTLA-4 protein in human Tregs is dependent on CTLA4 genotype.
Laura Esposito, Cambridge Institute for Medical Research, UK
13.30
Lunch and Workshop: 'Immunology & Publishing - Insights into what authors, editors and journals want'
Session 9 – Migration
Chair - Marc Jenkins
14.30
Short- and long-term consequences of dynamic T cell interactions with dendritic cell
Ulrich von Andrian, Harvard Medical School, USA
14.55
Assessing clonal deletion of polyclonal self-reactive CD4+ T cells
Marc Jenkins, University of Minnesota Medical School, USA
15.20
T cell receptor/MHC class II interactions in the thymic medulla set the activation threshold of CD4 T cells
Tom Li Stephen, University of Pennsylvania, USA
15.35
Lymph node-resident lymphatic endothelial cells mediate tolerance to tyrosinase via direct presentation and in an aire-independent manner
Cynthia Guidi, University of Virginia, USA
15.50
Immune therapies for autoimmune diseases: Thinking out of the box
Kevan Herold, Yale University School of Medicine, USA
16.20
Panel Discussion led by Kevan Herold
16.50
Closing remarks and end of conference
